Exelixis

• $30mm loan facility
• Form 8-K  12.21.07
• Loan and security agreement eighth amendment  12.21.08

Osiris Therapeutics

• $12mm private placement and common stock conversion
• Press release  12.20.07
• Convertible promissory note conversion agreement  12.19.07

Titan Pharmaceuticals

• $21.3mm private placement

• Press release  12.18.07
• Securities purchase agreement  12.17.07
• Letter agreement  11.28.07
• Registration rights agreement  12.17.07
• Warrant 

Cougar Biotechnology 

• $87mm private placement
• Press release  12.17.07
• Securities purchase agreement  12.14.07

• Registration rights agreement  12.14.07
• Prospectus  1.25.08

Discovery Labs   registered direct

• $25 mm registered direct offering
• Press release  12.12.07
• Prospectus  12.07.07
• FWP  12.07.07

Advanced Life Sciences

• $20mm private placement to new and existing investors
• Press release  12.11.07
• Securities purchase agreement 
• Form of warrant
• Prospectus  1.18.08

Cyclacel  equity financing facility

• $60mm committed equity financing facility
• Press release  12.11.07

• Warrant  12.10.07
• Registration rights agreement  12.10.07
• Common stock purchase agreement  12.10.07
• Prospectus  12.20.07

Third Wave Technologies  credit facility

• $25mm credit facility
• Press release  12.10.07

• Facility agreement   12.10.07
• Warrant agreement No. 1   12.10.07
• Warrant agreement No. 2  12.10.07
• Registration rights agreement  12.10.07

• Amendment to promissory note  12.10.07

SGX Pharmaceuticals  PIPE

• $25mm private placement
• Press release  11.20.07

• Form of warrant 
• Securities purchase agreement  11.19.07

• Prospectus  12.14.07

Epix  PIPE

• $16.3mm private financing
• Press release  11.12.07
• Securities purchase agreement  11.09.07

Molecular Insight   debt financing

• $150mm bond financing
• Press release  11.09.07

• Form 8-K  11.09.07
• Indenture  11.16.07

Chelsea Therapeutics  registered direct

• $48.9mm registered direct offering
• Press release  11.02.07
• Placement agency agreement  11.02.07

• Subscription agreement  11.01.07
• Prospectus supplement  11.01.07

Lev Pharmaceuticals  term loan facility

• $20mm senior secured term loan facility
• Press release  11.08.07
• Term note  11.02.07
• Warrant for purchase 

• Term loan agreement  11.02.07
• Pledge and security agreement  11.02.07
• Registration rights agreement  11.02.07

Favrille  registered direct

• $21.1 mm registered direct
• Press release  11.02.07
• Placement agent agreement  11.02.07

• Warrant to purchase common stock  11.07.07
• Prospectus supplement  11.02.07

Vanda  144A

• $100mm private placement of convertible senior notes
• Press release  10.31.07

Sequenom

• $30mm private placement
• Press release  10.26.07
• Purchase agreement  10.25.07

• Form S-3  11.05.07
• Prospectus  11.09.07

Optimer  PIPE

• $35.9mm private placement
• Press release  10.24.07
• Securities purchase agreement  10.23.07
• Registration rights agreement  10.23.07

Aastrom   registered direct

• $13.5mm registered direct offering
• Press release  10.16.07
• Placement agency agreement  10.15.07
• Escrow agreement  10.15.07
• Form of warrant   

• Common stock purchase warrant 
• Prospectus supplement  10.16.07

Cytokinetics   equity facility

• $75mm committed equity financing facility
• Press release  10.15.07
• Warrant
• Registration rights agreement  10.15.07

• Common stock purchase agreement  10.15.07
• Form S-3 prospectus summary  10.19.07

Dendreon  equity financing

• $130mm committed equity financing facility
• Press release  10.12.07

• Stock purchase agreement  10.11.07

CombinatoRx   common stock

• $35mm register direct common stock
• Press release  10.11.07
• Placement agent agreement  10.10.07

• Form of subscription agreement 
• Prospectus supplement  10.10.07

MannKind 

• $350mm off-balance sheet arrangement with principal stockholder
• Form 8-K  10.02.07
• Amended promissory note  10.02.07
• Stock purchase agreement  10.02.07  Alfred E. Mann

• Stock purchase agreement  10.02.07  Legg Mason

• Stock purchase agreement  10.02.07  Investors

Avicena

• $3.1mm private offering of preferred stock and warrants
• Press release  9.26.07

• Form 8-K  9.28.07
• Certificate of designation  9.24.07

• Form of Series

•  C-1 Warrant   C-2 Warrant   C-3 Warrant

• Securities purchase agreement  9.24.07
• Registration rights agreement  9.24.07

• Lock-up agreement  9.24.07

• Letter agreement  9.10.07

InterMune

• $68mm public offering of common stock
• Press release  9.21.07
• Underwriting agreement  9.20.07
• Prospectus supplement  9.20.07

Exelixis

• $71.8mm closing of public offering of common stock
• Form 8-K  9.11.07
• Underwriting agreement  9.10.07
• Prospectus supplement  9.10.07
• Form S-3  9.10.07

Medivation

• $100mm committed equity financing facility
• Press release  9.10.07
• Common stock purchase agreement  9.07.07
• Prospectus  9.10.07

Advanced Cell

• $10mm private placement
• Press release  9.04.07
• Securities purchase agreement  8.31.07
• Registration rights agreement 
• Common stock purchase warrant
• Amortizing senior secured convertible debenture
• Security agreement
• Subsidiary guarantee
• Lock-up letter  8.31.07

Nanogen

• $20mm registered unsecured senior convertible notes
• Press release  8.27.07
• Indenture  8.27.07
• First supplemental indenture  8.27.07
• Securities purchase agreement  8.26.07
• Placement agency agreement  8.26.07
• Form of notes 
• Form of series A warrant 
• Form of series B warrant
• Form of series C warrant

Isolagen

• $14mm registered direct common stock
• Press release  8.15.07
• Form of common stock purchase agreement  8.14.07

NPS Pharmaceuticals

• $100mm series B note backed by royalties
• Press release  8.07.07

Marshall Edwards  PIPE

• $16.4mm in private equity financing
• Press release  8.06.07
• Securities subscription agreement  8.01.07
• Registration rights agreement  8.06.07
• Warrant agreement  8.01.07

• Form of warrant 

BioCryst  PIPE

• $65mm in private placement
• Press release  8.06.07
• Form S-3  8.22.07
• Prospectus  8.30.07

Invitrogen

• $500mm buyback
• Press release  8.01.02

Lev Pharmaceuticals   registered direct

• $35mm in registered direct
• Press release  8.20.07
• Final prospectus  9.05.07

Neurobiological

• $65mm common stock
• Form S-1  8.13.07

Sangamo  PIPE

• $30mm of common stock to institutional investors
• Press release  7.17.07
• Placement agency agreement  7.16.07

• Form 8-K  7.17.07
• Prospectus supplement  7.18.07

GeoVax  PIPE

• $7.5mm private placement agreement 
• Press release  7.31.07
• Subscription agreement 

Kendle

• closes $200mm offering of convertible senior notes
• Press release  7.11.07
• Press release  7.16.07

• Underwriting agreement  7.10.07
• Supplemental indenture no.1  7.16.07

• Confirmation of transaction  7.10.07   UBS
• Confirmation of transaction  7.10.07   JPMorgan Chase

• Confirmation of issuer warrant  7.10.07 UBS
• Confirmation of issuer warrant  7.10.07 JPMorgan Chase
• Prospectus supplement  7.12.07
• Term sheet  7.10.07
• Indenture  3.21.07
• Form S-3  3.21.07

Inspire

• $75mm Warburg Pincus Ventures investment
• Press release  7.18.07
• Registration rights agreement  7.20.07
• First amendment to rights agreement  7.17.07

• Certificate of designations, number, voting powers, preferences and rights  7.19.07

• Certificate of amendment  7.19.07

• Securities purchase agreement  7.17.07
• Standstill agreement  7.20.07

Dyax  common stock

• pricing of public offering of common stock
• Press release  7.13.07
• Underwriting agreement  7.12.07

• Prospectus supplement  7.12.07

Indevus

• commences exchange offer for its 6.25% convertible senior notes due July 2008
• Press release  8.07.07  final results
• Form T-3  7.06.07
• Form of indenture 
• Statement of eligibility   7.03.07

Emergent BioSolutions  loan

• $30mm loan to support manufacturing expansion program
• Form 8-K  6.29.07
• Loan agreement  6.29.07

• Promissory note  6.29.07

VIA Pharmaceuticals  PIPE

• $25mm private placement of common stock
• Press release  6.29.07
• Securities purchase agreement
• Schedule 14C  7.17.07
• Press release  8.08.07

Peregrine  registered direct

• $22.5mm common stock in registered direct
• Press release  6.28.07
• Form 8-K
• Placement agent agreement
• Securities purchase agreement
• Prospectus supplement no.1  6.29.07

Panacos   debt financing

• $20mm debt financing
• Press release  6.28.07
• Form 8-K
• Prospectus supplement
• Warrant  6.28.07
• Loan and security agreement  6.28.07

ISTA Pharmaceuticals  PIPE 

• $36.75mm private placement of common stock
• Press release  6.27.07
• Purchase agreement
• Form S-3  7.05.07
• Prospectus  7.17.07

Biogen Idec  modified dutch auction

• $3b modified tender offer
• Press release 7.02.07  final results
• Press release  6.27.07
• Schedule TO  6.27.07
• Offer to purchase  5.30.07
• Letter of transmittal  5.30.07
• Broker dealer letter  5.30.07
• Client letter  5.30.07

• Summary advertisement  5.30.07
• Press release  5.30.07

Targeted Genetics   PIPE

• $19.5mm private placement of common stock  
• Press release  6.22.07
• Form 8-K
• Securities purchase agreement
• Registration rights agreement
• Common stock purchase warrant
• Press release  6.28.07
• Form S-3  7.11.07
• Prospectus  7.30.07

IDM Pharma  registered direct

• $23.5mm registered direct offering stock and warrants
• Press release  6.21.07

• Form 8-K
• Placement agent agreement

• Securities purchase agreement
• Common stock purchase warrant
• Prospectus supplement no.1  6.21.07

Micromet  PIPE

• $25mm private placement
• Press release  6.20.07
• Form 8-K
• Securities purchase agreement
• Common stock purchase warrant
• Registration rights agreement
• Form S-3  7.19.07
• Prospectus  8.03.07

Onyx  common stock

• $212.5mm public offering common stock
• Press release  6.21.07

• Underwriting agreement  6.20.07
• Prospectus  6.20.07

Osiris Therapeutics  PIPE

• $20mm private placement 
• Press release  6.06.07

• Form 8-K
• Subscription documents
• Letter agreement

Acorda Therapeutics  common stock

• $69.37mm public offering common stock
• Press release  6.04.07
• Form 8-K  6.04.07
• Prospectus supplement  6.07.07
• Prospectus supplement  6.04.07

Dendreon   convertible senior subordinated notes 

• $75mm convertible senior subordinated notes 
• Form 8-K  6.05.07
• Press release  6.06.07
• Purchase agreement  6.05.07
• Indenture  6.11.07
• Registration rights agreement  6.11.07
• S-3  8.10.07

Amylin  convertible senior notes

• $500mm private placement convertible senior notes
• Press release  6.05.07
• Form 8-K  6.04.07
• Press release  6.06.07  exercise option
• Purchase agreement  6.04.07
• Indenture  6.08.07
• Registration rights agreement  6.08.07
• Form S-3  8.07.07

American Oriental Bioengineering  common stock

• $72.25mm public offering common stock
• Prospectus  6.27.07
• Form S-3  6.04.07

Halozyme  PIPE

• $32.1 mm private placement of common stock  
• Form 8-K  4.23.07
• Stock purchase agreement  4.23.07

BioSante  PIPE

• $15.6 mm private placement of common stock 
• Press release  5.25.07  announced
• Form 8-K  5.25.07 
• Form 8-K  6.13.07  completed
• Subscription agreement
• Warrant  6.13.07
• Form S-3  7.17.07
• Prospectus  8.7.07

Amgen    PIPE

• $4b senior notes in a private placement 
• Press release  5.24.07
• Form 8-K
• Prospectus supplement  6.15.07
• Form S-3  3.08.06

Cell Genesys   registered direct

• $60mm registered direct common stock/warrants 
• Press release  4.11.07
• Form 8-K
• Placement Agency Agreement
• Warrant to Purchase Common Stock
• Subscription Agreement
• Prospectus supplement  4.11.07
• Term sheet  4.11.07

Genitope   common stock

• $21mm public offering common stock
• Press release  4.27.07
• Underwriting Agreement
• Prospectus Supplement

BioMarin   subordinated convertible notes

• $324.9mm sale of senior notes
• Form 8-K  4.17.07
• Purchase Agreement
• Second Supplemental Indenture
• Form of senior subordinated convertible notes
• Form S-3  3.20.06
• Prospectus  4.17.07

CytRx  PIPE

• $37mm private placement
• Press release  4.18.07
• Form 8-K
• Form of Purchase Agreement
• Form S-3  5.03.07
• Prospectus  5.21.07

Cell Genesys   registered direct

• $60mm registered direct common stock and warrants
• Press release  4.11.07
• Form 8-K
• Placement Agency Agreement
• Warrant to Purchase Common Stock
• Subscription Agreement
• Prospectus Supplement  4.11.07

Discovery Labs  registered direct

• $30mm in registered direct offering
• Press release  4.03.07
• Form 8-K
• Placement Agency Agreement
• Prospectus Supplement

Corcept  PIPE

• $9mm private equity financing 
• Press release  3.30.07
• Form 8-K
• Common Stock Purchase Agreement
• Form S-1  4.04.07

Manhattan Pharmaceuticals  PIPE

• $8.6mm private placement 
• Form 8-K  4.05.07
• Warrant for Purchase of Shares of Common Stock

• Warrant for Purchase of Shares of Common Stock - Paramount BioCapital
• Subscription Agreement
• Form S-3  5.03.07
• Prospectus  5.18.07

Acadia  common stock

• $89mm public offering common stock
• Press release  4.04.07
• Form 8-K
• Underwriting Agreement

• Final Prospectus Supplement

Bioenvision  registered direct

• $30 million in a registered direct offering
• Press release  4.02.07
• Form 8-K  3.30.07
• Placement Agency Agreement
• Prospectus Supplement