• $20 million common stock offering

• Prospectus supplement 11.14.05

• Common stock shelf registration

• Form S-3 1.20.05
• Cooley Godward opinion

• $150 million common stock offering
• Priced 10.26.05

• Form 8-K summary
• Underwriting agreement (Morgan Stanley)
• Wilmer Cutler legal opinion

• Prospectus supplement 10.25.05

• Announced 10.24.05

• Risk factors
• Prospectus supplement summary

• Prospectus supplement 10.24.05
• Additional shares registered 10.24.05

• Wilmer Cutler Hale opinion

• Common stock shelf registration

• Amendment #1 9.02.05
• Form S-3 8.19.05
• Wilmer Cutler Hale opinion

• Press release
• Prospectus supplement 10.12.05
• Form S-3

• Cooley Godward opinion

• Lazard / SG Cowen

• Press release
• Prospectus 10.07.05

• Amendment #1
• Form S-1
• Underwriting agreement (CIBC)

• Press release
• Press release
• Prospectus supplement 9.26.05

• Pricing agreement
• Form S-3 5.23.05
• Underwriting agreement (Goldman)

• Sells $22.6 million in a registered direct offering
• Sold at $4.80 per share; Stock declines in response
• Press release 10.12.05
• Form 8-K
• Prospectus supplement
• Placement agency agreement
• VICL stock chart

• Sells stock and warrants in a registered direct offering
• Raises $18.9 mm, net; Stock declines in response
• Press release 9.28.05
• Form 8-K
• Warrant
• Prospectus supplement 9.29.05
• Form S-3 6.20.05
• Placement agency agreement
• Risk factors
• Morgan Lewis opinion
• NGEN stock chart

• Sells $19.7 million in a registered direct offering
• Sold at $4.75 per share; Stock declines in response
• Cell-based research and diagnostic products

• Initial focus on cancer
• Business

• Press release 6.29.05
• Form 8-K
• Prospectus supplement
• Placement agency agreement

• Legg Mason / First Albany
• Morgan Lewis

• Form S-3 5.06.05
• Slide presentation 5.04.05
• IMMC stock chart

• $50 million exchangeable preferred stock

• Warburg Pincus investment
• 43% of pro forma shares outstanding

• Press release 3.03.05
• Form 8-K

• Summary of financing
• Terms of exchangeable preferred

• Securities purchase agreement*

• Preferred stock designations
• Registration rights agreement
• Standstill agreement
• Rights agreement amendment
• Schedule 13D

• Placement agent agreement (Needham & Co)

Additional investment - FrontPoint Healthcare

Shareholder approval (per NASDAQ rules):

SEC registration

• $14.7 million sale of common stock and warrants

• Oppenheimer - Griffin Securities, placement agent
• Sold at $4.00 per share; 737,000 warrants

• Press release 10.19.05
• Form 8-K 10.20.05
• Form 8-K 10.25.05
• Form 8-K 10.28.05
• Form S-3 11.15.05

• $20 million equity line from Fusion Capital
• Press release 10.24.05
• Form 8-K 10.24.05
• Common stock purchase agreement
• Registration rights agreement
• Form S-1 11.04.05

• Torys opinion

• GLGS stock chart

• $75 million equity line from Kingsbridge Capital
• Press release 10.14.05
• Form 8-K 10.18.05
• Form S-3 11.09.05
• TRCA stock chart

• $15 million equity line from Southridge Capital Management
• Form 8-K
• Private equity credit agreement
• Form S-1/A 11.09.05
• Withdraw registration 1.13.06
• LSBC.PK stock chart

• Doubles shares outstanding with $66 million raise
• Executives paid retention bonuses
• Press release 10.07.05
• Summary
• Securities purchase agreement
• Warrant
• Registration rights agreement
• LJPC stock chart

• Press release 10.03.05
• Form 8-K
• Securities purchase agreement *
• Warrant
• MBRX stock chart

• $7.2 million raise
• Press release 9.29.05
• Form 8-K
• Securities purchase agreement
• Warrant
• Warrant
• Registration rights agreement
• LIPD stock chart

• $35 million two-year commitment by Cornell Capital
• Press release 9.29.05
• Form 8-K
• Standby equity distribution agreement
• Placement agent agreement
• TTP stock chart

• $51 million raise
• Press release 8.19.05
• Form 8-K
• Securities purchase agreement
• Warrant
• Form S-3 9.07.05

• Prospectus 11.02.05

• ISIS stock chart
• SEC Comment Letters

• SEC Comment Letter 9.09.05
• ISIS Response  10.28.05

• ISIS Response 10.31.05

• Raises $16.8 million
• Press release 8.16.05
• Form 8-K
• Securities purchase agreement
• Registration rights agreement
• Warrant

• Raises $23.0 million
• Press release 8.09.05
• Form 8-K
• Schedule 13D
• Stock purchase agreement
• Form S-3 9.07.05

• Prospectus supplement 10.14.05
• Latham opinion

• Raises $6.5 million

• More than doubles shares outstanding
• Summary
• GLGS stock chart

• Press release 3.04.05

• Form 8-K

• Securities purchase agreement

• Preferred stock designations
• Warrant
• Registration rights agreement

• Shareholder approval

• Definitive proxy statement 3.30.05
• Amendment #1 3.24.05
• Preliminary proxy statement 3.16.05

• Threatened Nasdaq delisting

• Summary
• Form 8-K 4.12.05
• Form 8-K 4.26.05

• SEC registration

• Form S-3 4.29.05
• Torys opinion

• Prices $5 billion offering

• $2.5B five-year senior notes
  ◊  0.125% / 11% conversion premium

• $2.5B seven-year senior notes
  ◊  0.375% / 10.5% conversion premium
• Deal involved sale of warrants to
  effectively raise the conversion premium to 50%

• Deal was placed privately per Rule 144A

• Proceeds will fund $3B common stock repurchase
• Deal size was increased by $1 billion

• Press release 2.14.06
• Press release 2.13.06

• Convertible senior notes

• $82mm offering

• Press release 11.01.05

• Form 8-K

• Conversion and placement agreement 10.31.05

• Convertible subordinated notes and warrants

• $35mm offering
• Prospectus 10.17.05

• Amendment #1 10.12.05
• Form S-3 9.14.05
• Form T-1

• Morgan Lewis

• Press release 4.27.05

• Form 8-K

• Purchase agreement 4.27.05

• Warrant
• Indenture
• Registration rights agreement

• Convertible subordinated notes

• $230mm 7-year 2-1/4%

• Press release 8.09.05

• Form 8-K

• Purchase agreement 8.04.05

• Indenture
• Registration rights agreement

• Form S-3 10.07.05

• Prospectus 10.14.05
• Cooley Godward

• Form S-3 10.21.05

• Indenture
• Palmer Dodge

• Form S-3 10.13.05

• Participating preferred stock
• Cooley Godward

• Form S-3 10.13.05

• Participating preferred stock
• Heller Ehrman

• Press release 10.11.05
• Form S-3 10.11.05

• Indenture (Senior debt)
• Indenture (Subordinated debt)
• Form T-1
• Form T-1
• Dickstein Shapiro

• Form S-3 10.06.05

• Indenture (Senior debt)
• Indenture (Subordinated debt)
• Warrant (Common stock)
• Warrant (Preferred stock)
• Warrant (Debt)
• Form T-1
• Form T-1
• Cooley Godward

• Form S-3 10.03.05

• Ropes & Gray

• Form S-3 9.30.05

• Ropes & Gray

• Form S-3 9.23.05

• Mintz Levin

• Form S-3 9.09.05

• Indenture (Senior debt)
• Indenture (Subordinated debt)
• Warrant (Common stock)
• Warrant (Preferred stock)
• Warrant (Debt)
• Cooley Godward

• $5 million revolving credit facility from Silicon Valley Bank
• Press release 10.06.05
• Form 8-K
• Loan and security agreement 10.05.05

• $18 million loan from Silicon Valley Bank
• To expand biologics manufacturing facility
• Press release 12.28.04
• Form 8-K summary
• Loan and security agreement 12.23.04
• Lease amendment